• Cholecalciferol (Vitamin D3) is a fat-soluble prohormone that undergoes two-step activation:
• Liver: Converted to 25-hydroxyvitamin D (calcidiol)
• Kidney: Further hydroxylated to 1,25-dihydroxyvitamin D (calcitriol), the active form.
• Calcitriol binds to Vitamin D Receptors (VDRs) in targeted tissues, regulating gene expression involved in:
• Calcium and phosphate absorption from the gut
• Bone mineralization and remodeling
• Muscle contraction and nerve conduction
• Immune modulation and neuroprotection

Indications:

• Musculoskeletal Disorders:
• Chronic low back pain
• Osteoarthritis
• Rheumatoid arthritis
• Neurological Conditions:
• Neurodegenerative disorders
• General Deficiency States:
• Vitamin D deficiency and insufficiency
• Associated fatigue, bone pain, and muscle weakness

Clinical Advantages:

• Superior Absorption: Nano droplet oral solution ensures enhanced bioavailability.
• Neuroprotective Action: Helps maintain blood-brain barrier integrity and supports neuronal health.
• Bone & Muscle Support: Maintains calcium-phosphate balance essential for skeletal strength and muscle function.
• Weekly Dosing Efficiency: 60,000 IU weekly is more effective than daily 1,000 IU in rapidly correcting deficiency.
• Sugar-Free Formulation: Suitable for diabetic and calorie-conscious patients.
• Dual Format Convenience: Available as chewable tablets and oral solution for flexible patient compliance.

“Power up with the sunshine dose—strong bones, sharp mind, steady mood.”

Thiocolchicoside (THIOTENSE)

* Semi-synthetic derivative of colchicoside

* Binds to GABA-A and glycine receptors

* Acts at the supraspinal level to relieve muscle spasms

* Also exhibits anti-inflammatory and analgesic properties

* Non-sedative: preserves alertness and daily function

Aceclofenac (in THIOTENSE-AC)

* Inhibits COX enzymes, reducing prostaglandin synthesis

* Suppresses IL-1, TNF, and PGE2—key drivers of inflammation

* Deep tissue penetration ensures targeted joint relief

Indications:

* Acute and chronic low back pain

* Cervical and lumbar spondylosis

* Muscle spasms of traumatic or rheumatic origin

* Arthritis and inflammatory joint disorders

* Fever with musculoskeletal pain

Clinical Advantages:

* Dual-action relief: muscle relaxation + inflammation control

* Non-sedative: ideal for active patients

* Fast onset and sustained comfort

* Available in 4 mg & 8 mg capsules and AC combinations

* Backed by pharmaco-EEG and animal model validation

Mechanism of Action:

* Blocks voltage-gated sodium and calcium channels at the spinal cord level

* Inhibits presynaptic neurotransmitter release, reducing reflex muscle contractions

* Enhances skeletal muscle blood flow, relieving ischemia-induced pain

* Exhibits membrane-stabilizing and local anesthetic properties

* Provides antinociceptive activity against thermal stimulation

Indications:

* Low back pain syndrome

* Painful reflex muscle spasm

* Post-stroke spasticity

* Neurolathyrism

* Trapezitis

* Periarthritis

* Rehabilitation programs

Clinical Advantages:

* Effective in reducing muscle spasm and improving mobility

* Superior tolerability compared to thiocolchicoside in clinical trials

* Improves daily activity performance with minimal sedation

* Safe for use in elderly and comorbid patients

* 92% of patients reported no adverse events in post-marketing surveillance

* Detectable improvement in Lasegue’s score and finger-to-floor distance within 7 days

 TOLPICRON – Calm the spasm. Restore the rhythm

Note: To be used only under the guidance of a registered medical practitioner.